Target intelligence / Profile preview

MicroRNA 4522 (MIR4522)

Target
MIR4522
Molecular classification
Non-coding RNA, MicroRNA (miRNA), Other (gene expression regulator)
01

Overview

MicroRNA 4522 is a small, single-stranded non-coding RNA molecule that belongs to the microRNA family, functioning primarily in the post-transcriptional regulation of gene expression. Like other miRNAs, MIR4522 is processed from a precursor transcript in the nucleus and exerts its function in the cytoplasm by associating with the RNA-induced silencing complex (RISC), guiding the complex to target mRNAs through sequence-specific base-pairing, and regulating their stability and translation. MicroRNAs broadly control essential cellular processes including proliferation, differentiation, and survival, and their aberrant expression has been linked to a wide range of diseases, particularly cancers, although no specific disease role for MIR4522 is present in the provided search results.

Other names
hsa-mir-4522MIR4522microRNA 4522
02

Mechanism of action

Gene silencing by complementary base-pairing to target mRNAs, usually at the 3' untranslated region, resulting in mRNA degradation or translational repression\nModulation of cell fate via regulation of gene networks relevant to apoptosis, proliferation, differentiation, and survival

03

Biological functions

RNA silencingPost-transcriptional gene expression regulationCell proliferationCell differentiationCell survival
04

Disease associations

Potential roles in cancerOther (miRNAs can be implicated in inflammation, neurodegenerative diseases, cardiovascular diseases, infection)
05

Safety considerations

No explicit safety concerns for therapies targeting MIR4522 are noted. For miRNA-targeted therapies, general concerns include off-target effects, unintended modulation of multiple genes, immune activation, and delivery challenges.

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