microRNA 4534 (miR-4534)

microRNA 4534 (miR-4534) is a small (20–24 nucleotides) non-coding RNA molecule that regulates gene expression by binding to complementary sequences in target mRNAs, leading to translational inhibition or degradation of the target mRNA[6][10]. It has been found to act as an oncogenic microRNA in prostate cancer by directly targeting and downregulating PTEN, a tumor suppressor gene involved in the PI3K/Akt signaling pathway, contributing to increased cell proliferation, migration, and survival[2][7]. miR-4534 is upregulated in prostate cancer cells versus normal tissues and is associated with poor clinical outcomes[2][7]. It has also been identified as a urinary exosomal biomarker in diabetic kidney disease, where it may influence the FoxO signaling pathway by targeting BNIP3[1]. Therapeutic or biomarker approaches involving miR-4534 face challenges typical of microRNA-based strategies, including specificity and off-target effects.

Other names

MIR4534hsa-mir-4534miR-4534

Downregulation of tumor suppressor genes (e.g., PTEN) via direct binding to messenger RNA, reducing its translation or triggering its degradation[2][7]