microRNA 454 (miR-454)

MicroRNA 454 is a human non-coding RNA of approximately 23 nucleotides classified as a microRNA, which functions in gene regulation through post-transcriptional repression of specific mRNAs. miR-454 displays context-dependent roles—serving as an oncogene or a tumor suppressor—in various cancers such as breast, lung (NSCLC), colorectal, hepatocellular carcinoma, glioma, and melanoma. In breast cancer, high miR-454 levels are linked to poor prognosis and reduced disease-free survival, particularly in triple-negative subtypes, and it may predict diminished response to certain chemotherapies (anthracyclines). miR-454 affects cell proliferation, migration, invasion, cell cycle, and EMT by targeting genes involved in these pathways (e.g., STAT3, FoxJ2/E-cadherin, Runx3, IGF2BP1, ZEB2). Its dual roles—tumor suppression in some cancers and oncogenic activity in others—make it relevant as both a biomarker for prognosis and as a potential therapeutic target, though with substantial challenges in clinical application due to its variable functions and broad biological impact.

Other names

hsa-mir-454mir-454MIRN454MIR454microRNA-454miR-454miR-454-3pmiR-454-5p

miR-454 acts by post-transcriptional repression of target mRNAs of protein-coding genes, affecting pathways such as STAT3, FoxJ2/E-cadherin, IGF2BP1, ZEB2, CHD5, and Runx3. Its role encompasses both suppression and activation of tumor progression, depending on cancer type and specific mRNA targets.