MicroRNA 4638 (miR-4638)

MicroRNA 4638 (miR-4638) is a small, non-coding RNA molecule found in human cells. It belongs to the microRNA family of gene regulators which typically act by base-pairing with messenger RNA (mRNA) transcripts to repress their translation or promote their degradation. In breast cancer, miR-4638-3p acts as a tumor suppressor, where its overexpression reduces bone metastatic potential and suppresses markers of bone resorption in experimental models. In these contexts, miR-4638 was shown to target the mRNA of activating transcription factor 3 (ATF3), reducing its expression and thereby impacting cell proliferation, invasion, and metastatic niche formation. Its role as a therapeutic target or biomarker is still under investigation, with no known pharmaceutical agents directly interacting with this molecule in clinical practice[1][2]. MicroRNA 4638 is not a classical receptor, enzyme, transporter, or protein target; it is a regulatory RNA molecule that modulates gene expression post-transcriptionally and is under investigation for its tumor suppressor activity in specific cancers, primarily breast cancer bone metastasis[1][2].

Other names

hsa-mir-4638mir-4638MIR4638miR-4638-3p

Not as a direct drug target; overexpression modulates tumor cell gene expression by targeting ATF3 mRNA, leading to reduced bone metastatic activity