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MicroRNA 4644 (miR-4644 (or hsa-miR-4644 for human-specific reference))
- Target
- miR-4644 (or hsa-miR-4644 for human-specific reference)
- Molecular classification
- MicroRNA, Non-coding RNA, Regulatory RNA
01
Overview
MicroRNA 4644 (miR-4644) is a small non-coding RNA molecule belonging to the microRNA family, which functions as a post-transcriptional regulator of gene expression[2][3]. In human biology, miR-4644 is upregulated in plasma exosomes of bladder cancer patients and acts as a pro-tumorigenic miRNA by downregulating its target gene UBIAD1, a tumor suppressor, thereby promoting cell proliferation, invasion, and migration in bladder cancer cells[2]. Its differential expression in cancer makes it a candidate biomarker for diagnosis and prognosis. As a microRNA, it does not encode a protein but regulates the translation and degradation of specific messenger RNAs[3].
- Other names
- hsa-miR-4644MIR4644miRNA 4644hsa-mir-4644
02
Biological functions
Gene regulation (post-transcriptional)Cell proliferationCell migrationCell invasionPotential regulation of cell death (apoptosis)
03
Disease associations
Cancer (notably bladder cancer; also suggested for pancreatobiliary tract cancers)
04
Safety considerations
Potential off-target regulation due to promiscuity of miRNA-mRNA interactionsLimited knowledge regarding broad biological impact and safety in therapeutic targeting
05
Biomarkers
Circulating miR-4644 in plasma exosomes (as a biomarker for bladder cancer and possibly for pancreatobiliary tract cancer)
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