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Target intelligence / Profile preview
MicroRNA 4647 (miR-4647)
- Target
- miR-4647
- Molecular classification
- MicroRNA, Non-coding RNA, Other
01
Overview
MicroRNA 4647 (miR-4647) is a small non-coding RNA molecule that functions to regulate gene expression by binding to complementary sequences in the 3′ untranslated regions (3′UTRs) of target mRNAs, leading to their translational repression or degradation. It has been implicated in the pathogenesis and progression of colorectal cancer by downregulating MUC13 expression, which in turn affects cell proliferation and migration. miR-4647 expression is also associated with overall survival in patients with colorectal cancer and is studied as a biomarker in chronic myeloid leukemia for predicting response to imatinib therapy. As a microRNA, miR-4647 is part of the broader family of non-coding RNAs with key regulatory functions in health and disease[1][3].
- Other names
- hsa-mir-4647mir-4647MIR4647hsa-miR-4647
02
Mechanism of action
miR-4647 binds to specific mRNA targets (notably MUC13 and TNFRSF13C) leading to their translational repression or degradation[1]
03
Biological functions
Post-transcriptional gene silencingRegulation of gene expressionModulation of cell migrationSuppression of colony formationOther
04
Disease associations
CancerColorectal cancerChronic myeloid leukemiaOther
05
Safety considerations
None specifically reported; but miRNA-based therapeutics face general challenges such as off-target effects, immune reactions, and delivery to target tissues
06
Interacting drugs
Imatinib (as biomarker context)[1]
07
Biomarkers
miR-4647 expression level (potential biomarker for colorectal cancer prognosis and patient selection in chronic myeloid leukemia, especially for imatinib discontinuation trials)[1]
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