MicroRNA 4651 (miR-4651)

MicroRNA 4651 (miR-4651) is a small non-coding single-stranded RNA (approximately 18–24 nucleotides) encoded on chromosome 7, functioning as a post-transcriptional regulator of gene expression. It is downregulated in hepatocellular carcinoma (HCC), and its overexpression suppresses tumor cell growth and promotes apoptosis, in part by directly targeting and downregulating forkhead box protein P4 (FOXP4). miR-4651 is also suggested to act as a tumor suppressor and potential prognostic biomarker for HCC progression[1]. No drugs are currently in clinical use directly targeting miR-4651, but chemically modified oligonucleotide inhibitors are commercially available for research purposes[2].

Other names

hsa-miR-4651MIR4651mir-4651hsa-mir-4651

Not applicable for direct drugs; miR-4651 acts by binding to target mRNAs and repressing gene expression, primarily via translational inhibition or mRNA degradation[1].