MicroRNA 4652 (MIR4652)

MicroRNA 4652 (MIR4652, hsa-mir-4652) is a small non-coding RNA belonging to the microRNA family, typically 19–25 nucleotides in length[2][5]. It regulates gene expression post-transcriptionally by binding to complementary sequences in messenger RNAs, resulting in translational repression or mRNA degradation[2]. Recent studies implicate hsa-miR-4652-5p in the progression of neurodegenerative diseases such as Alzheimer’s disease, suggesting its potential use as a biomarker for early diagnosis[6]. While the precise mRNA targets of MIR4652 require further elucidation, bioinformatic pathway analyses predict involvement in major regulatory pathways such as PI3K-Akt, JAK/STAT, and p53 signaling[6]. To date, no approved drugs target this specific microRNA, but it is considered a potential future therapeutic target given the expanding role of microRNAs in disease biology.

Other names

hsa-mir-4652hsa-miR-4652MIR4652

Not available for specific drugs (general mechanism: microRNA-based therapeutics usually act via antisense oligonucleotides, miRNA mimics, or inhibitors, modulating expression or activity of the target microRNA and thereby affecting downstream gene expression)