microRNA 4653 (miR-4653)

microRNA 4653 (miR-4653, specifically miR-4653-3p) is a small non-coding RNA molecule that regulates gene expression post-transcriptionally by binding to the 3'-untranslated regions of target messenger RNAs, leading to their degradation or translational repression. It is not a traditional therapeutic target such as a receptor or enzyme, but rather functions as a regulator in gene networks. Upregulation of miR-4653-3p has been linked to aggressive features and poor prognosis in pancreatic ductal adenocarcinoma, likely through direct downregulation of HIPK2, a tumor suppressor gene[1]. Expression alterations of miR-4653-3p occur in various tumors including breast cancer, glioblastoma, and nasopharyngeal carcinoma, and it plays a role in tumorigenesis, progression, and potential metastatic behavior[1].

Other names

hsa-mir-4653miR-4653-3pMIR4653