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Target intelligence / Profile preview
microRNA 4658 (MIR4658)
- Target
- MIR4658
- Molecular classification
- microRNA, Non-coding RNA, Small RNA
01
Overview
microRNA 4658 (MIR4658) is a small (typically 21–24 nucleotides long), single-stranded, non-coding RNA molecule that functions to regulate gene expression at the post-transcriptional level. Like other microRNAs, it acts via sequence-specific base-pairing to target messenger RNAs, leading to their translational repression or degradation. The specific biological functions and disease associations of MIR4658 are not well described, reflecting the broader situation for many individual human miRNAs beyond the most intensively studied. MIR4658 may participate in regulatory networks implicated in cellular homeostasis, but detailed target genes or clinical relevance remains to be elucidated. Inhibitors of MIR4658 are available as research reagents, but no approved drugs are known to target it.
- Other names
- hsa-mir-4658hsa-miR-4658MIR4658
02
Mechanism of action
Antisense oligonucleotides hybridize with the mature MIR4658, blocking its function. This typically results in the derepression of its mRNA targets.
03
Biological functions
Post-transcriptional regulation of gene expressionRNA silencingGene regulatory function, including repression and fine-tuning of mRNA translation and stability
04
Disease associations
No specific disease associated with microRNA 4658 in the provided results. However, microRNAs in general frequently participate in:CancerCardiovascular diseaseNeurological diseaseOther (context-dependent; applies to the miRNA class generally, with no evidence specific for MIR4658)
05
Safety considerations
None reported specifically for MIR4658.For the microRNA class, off-target effects, functional redundancy, and unintended fine-tuning of essential cellular pathways are general concerns with therapeutic targeting.There are also concerns about delivery and stability for oligonucleotide-based therapies.
06
Interacting drugs
None specifically identified for MIR4658.
1 more in the full profile.
07
Biomarkers
No specific biomarkers for MIR4658 are identified, but circulating microRNAs can serve as general biomarkers in a range of diseases.IsomiRs (variant miRNA species) may also serve as biomarkers, but this has not been directly attributed to MIR4658
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