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MicroRNA 4662a (MIR4662A)

Target
MIR4662A
Molecular classification
MicroRNA (miRNA), Non-coding RNA
01

Overview

MicroRNA 4662a (MIR4662A) is a small, non-coding RNA molecule (typically 20-24 nucleotides) that regulates gene expression by binding imperfectly to target messenger RNAs (mRNAs), primarily leading to translational inhibition or mRNA destabilization. It belongs to the miRNA family, which are produced via a canonical biogenesis pathway involving Drosha and Dicer enzymes. The mature miRNA is loaded into the RNA-induced silencing complex (RISC), which mediates gene silencing. As with other miRNAs, MIR4662A may modulate biological processes such as cell differentiation, cell cycle, apoptosis, and immune responses, although specific functional and disease roles have not been individually characterized for this miRNA. MicroRNAs, including MIR4662A, are studied as potential therapeutic targets and biomarkers, particularly in cancer and other diseases where their regulatory networks are disrupted. No direct therapeutic drugs or validated biomarker applications specifically for MIR4662A are reported in the current literature or major databases. Safety and efficacy concerns typical for microRNA-targeted interventions include the risk of unintended regulation of multiple genes and disruption of complex biological networks.

Other names
hsa-mir-4662amicroRNA 4662aMIR4662A
02

Biological functions

Post-transcriptional regulation of gene expressionTranslational inhibition and mRNA destabilizationFine-tuning cell differentiation, proliferation, and apoptosisMaintaining cell fate and pluripotency
03

Disease associations

CancerOther diseases (e.g., immune regulation, development, cardiovascular, renal disease)
04

Safety considerations

Off-target gene regulationBroad impact on gene networks and phenotypic plasticity, which may create therapeutic challenges
05

Biomarkers

Potential circulating miRNA biomarker

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