MicroRNA-467a-3p (miR-467a-3p)

MicroRNA-467a-3p is a small, single-stranded, non-coding RNA molecule that functions as a post-transcriptional regulator of gene expression by binding to specific messenger RNAs (mRNAs) and inhibiting their translation or promoting their degradation[7][1]. It has been shown to regulate the **stemness** (self-renewal capacity) and **myogenesis** (muscle cell formation) of satellite cells, which are key for muscle maintenance and regeneration. Dysregulation of miR-467a-3p can contribute to conditions like sarcopenia, an age-associated disease characterized by muscle loss and functional decline. Therapeutic strategies targeting miR-467a-3p, such as antagomiRs and miRNA mimics, are under exploration for influencing satellite cell behavior and for potential use in muscle-degenerative diseases[1][3][5].

Other names

miR-467a-3pmmu-miR-467a-3p (mouse ortholog designation)

AntagomiR-467a-3p: Competitive inhibition of endogenous miR-467a-3p, preventing it from binding its target mRNAs, thereby upregulating target gene expression[1]. miR-467a-3p mimic: Introduction of synthetic miRNA to mimic the function of endogenous miR-467a-3p, increasing suppression of target mRNAs[3][5].