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MicroRNA 4680 (MIR4680)
- Target
- MIR4680
- Molecular classification
- microRNA (miRNA), Non-coding RNA
01
Overview
MicroRNA 4680 (MIR4680) is a short, non-coding RNA (miRNA) whose mature form mediates post-transcriptional gene silencing by binding target mRNAs and inhibiting their translation or promoting degradation. In human embryonic palatal mesenchymal (HEPM) cells, MIR4680 is upregulated by environmental agents such as *all-trans retinoic acid* and *phenytoin*, leading to suppressed proliferation and downregulation of key genes required for normal palate development, including *ERBB2* and *JADE1*. These findings have implicated MIR4680 as a potential genetic and pharmacological target in the study and prevention of congenital cleft palate
- Other names
- hsa-mir-4680miR-4680-3pMIR4680microRNA 4680
02
Mechanism of action
Drug-induced upregulation of MIR4680 suppresses cell proliferation by downregulating ERBB2 (a receptor tyrosine kinase), JADE1 (a nuclear protein), and other predicted targets
03
Biological functions
Post-transcriptional regulation of gene expressionNegative regulation of cell proliferationRegulation of genes involved in palate morphogenesis
04
Disease associations
Cleft palate / craniofacial developmental abnormalitiesPotentially relevant in birth defects caused by environmental or drug-induced factors (e.g., retinoic acid, phenytoin)
05
Safety considerations
Overexpression or activation may cause abnormal palate development (cleft palate)Altered expression has implications for developmental toxicity in response to drugs or environmental factors
06
Interacting drugs
All-trans retinoic acid (atRA)
1 more in the full profile.
07
Biomarkers
MIR4680 expression can be used to monitor risk for cleft palate or response to teratogenic compounds in model systems
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