microRNA 4691 (MIR4691)

MicroRNA 4691 (MIR4691) is a human microRNA; a single-stranded, non-protein coding RNA of approximately 19–25 nucleotides in length. MicroRNAs bind to complementary sequences in the 3′ untranslated regions (UTRs) of target mRNAs and repress their translation or cause degradation. Specifically, miR-4691-3p has been shown to participate in the regulation of inflammation in human dental pulp by directly targeting the STING protein, thereby inhibiting the cGAS-STING innate immune pathway and downstream cytokine production such as IFN-β, TNF, and IL-6. There are no known transcripts produced from the MIR4691 gene itself, consistent with typical microRNA gene function, and its roles are achieved through post-transcriptional gene silencing. In research settings, synthetic inhibitors and agomirs are available to suppress or mimic miR-4691-3p, facilitating functional studies of its biological impact. There are currently no approved drugs directly targeting MIR4691 in clinical practice.

Other names

hsa-mir-4691mir-4691hsa-miR-4691-3phsa-miR-4691-5p

Antisense inhibition of the mature miRNA (for the inhibitor); Mimicry or overexpression of the miRNA function (for the agomir/miRNA mimics)