MicroRNA 4711 (MIR4711 (miR-4711))

MicroRNA 4711 (miR-4711) is a member of the microRNA class—short (20-24 nucleotide) non-coding RNAs involved in post-transcriptional regulation of gene expression by base-pairing to target mRNAs and typically repressing translation or destabilizing the mRNA[1][2]. miR-4711 has been studied particularly in the context of cancer biology, where it regulates cancer stemness and cell cycle progression in colon cancer cells, affecting key oncogenic regulators such as KLF5, MDM2, and TFDP1[1]. Like other microRNAs, miR-4711 is produced by sequential processing of primary transcripts (pri-miRNA) through the action of Drosha and Dicer endonucleases, and incorporated into the RNA-induced silencing complex (RISC) to exert its function[1][2]. MicroRNAs impact various biological processes, including cell proliferation, differentiation, and survival, and their dysregulation is implicated in multiple diseases, particularly cancer[1][2][3][4].

Other names

miR-4711-5phsa-mir-4711MIR4711

Anti-miRNA oligonucleotides inhibit miRNA function via hybridization and RNase-dependent degradation or sequestration; miRNA mimics restore or enhance target miRNA regulatory activity.