MicroRNA 4713 (miR-4713)

MicroRNA 4713 is a small, non-coding RNA molecule that functions as a post-transcriptional regulator of gene expression. Like other microRNAs, it does not encode a protein but instead binds to complementary sequences in target messenger RNAs (mRNAs), typically resulting in translational repression or degradation of the target mRNA[1][7]. MicroRNA 4713 (often specifically studied as miR-4713-3p) has been shown to directly target the mRNA of epoxide hydrolase 3 (EPHX3), suppressing its expression and thereby promoting malignant progression, cell proliferation, migration, and invasion in nasopharyngeal carcinoma cells[2]. Its upregulation enhances Wnt/β-catenin pathway activity and contributes to epithelial-mesenchymal transition, processes central to cancer invasion and metastasis[2]. Additionally, miR-4713 is associated with obesity, being downregulated in adipose tissue from obese individuals and linked to regulation of genes such as NPY1R in metabolic pathways[3]. As a microRNA, it belongs to the 'Other' molecular class (non-coding RNA) rather than classic therapeutic target classes like enzyme or receptor. There is currently no evidence of clinically approved drugs that directly target miR-4713, but modulation of its activity is of emerging research interest, both as a potential biomarker and as a putative experimental therapeutic target in cancer and metabolic disease[2][3].

Other names

hsa-mir-4713hsa-miR-4713MIR4713miR-4713-3p

Post-transcriptional repression of target mRNA (e.g., downregulation of EPHX3 mRNA), Inhibition of translation, mRNA degradation, Modulation of signaling pathways (Wnt/β-catenin)