microRNA 4715 (miR-4715)

microRNA 4715 (miR-4715, hsa-miR-4715-3p) is a small, non-coding RNA molecule classified as a microRNA, typically composed of 21–23 nucleotides. Like other microRNAs, it functions primarily by binding complementary sequences on specific messenger RNAs, mediating post-transcriptional gene silencing through inhibition of translation or degradation of the target mRNA. Recent studies have implicated miR-4715-3p in the modulation of immune cell processes, particularly macrophage infiltration and pyroptosis, through a regulatory axis with the protein Gasdermin D during the progression of nonalcoholic fatty liver disease (NAFLD). Its role as a disease biomarker is emerging in liver fibrosis, although there is only limited evidence so far for this specific microRNA in other diseases such as cancer. As a microRNA, miR-4715 is not classified as a receptor, enzyme, transporter, or typical drug target, but instead is a regulatory RNA molecule.

Other names

MIR4715hsa-mir-4715hsa-miR-4715-3p

Small RNA-induced silencing, typically through binding to the 3' UTR of messenger RNA to suppress translation or promote mRNA decay