microRNA 4732 (miR-4732 (also, miR-4732-5p and miR-4732-3p for strands))

MicroRNA 4732 (miR-4732) is a short, non-coding RNA involved in post-transcriptional regulation of gene expression, acting as a gene silencer by binding target mRNAs, leading to their degradation or translational inhibition[1]. MiR-4732 is encoded in the human genome and gives rise to two mature strands (miR-4732-5p and miR-4732-3p). It has been implicated in the regulation of cell proliferation, migration, invasion, and apoptosis in various cancer models, with context-dependent roles as an oncogene or tumor suppressor. In ovarian cancer, miR-4732-5p is upregulated and promotes cell mobility, in part by suppressing MCUR1, and its expression is associated with poorer prognosis and is being evaluated as a circulating biomarker[1]. In breast cancer patients, miR-4732-3p levels are linked with risk of anthracycline-induced cardiotoxicity and may confer cardioprotection in cell models[3]. In infectious disease, circulating miR-4732-5p helps discriminate patients with nontuberculous mycobacterial pulmonary disease[2]. There are currently no drugs targeting miR-4732 in clinical use, but it remains a potential biomarker and research target in precision medicine.

Other names

hsa-mir-4732mir-4732hsa-miR-4732-5pmiR-4732-5phsa-miR-4732-3pmiR-4732-3p

Not applicable for drugs directly binding miR-4732. Indirectly, miR-4732 mimics or inhibitors can be used as gene therapy tools to alter expression, leading to effects on proliferation, invasion, or cell death via regulation of downstream targets such as MCUR1, TSPAN13, or by modulation of PI3K/AKT pathways