MicroRNA 4739 (miR-4739)

MicroRNA 4739 (miR-4739) is a small, non-coding RNA molecule that regulates gene expression post-transcriptionally, primarily by binding to complementary sequences in target mRNAs and inhibiting their translation or promoting their degradation[1][2]. In esophageal squamous cell carcinoma cells, miR-4739 acts as a tumor suppressor by decreasing cell proliferation, migration, and invasion, and by inducing apoptosis. It achieves these effects partly through direct repression of HOXC10 mRNA, which in turn reduces angiogenesis via the VEGFA/PI3K/AKT signaling axis[1]. In clinical studies, circulating levels of miR-4739 have been proposed as biomarkers for critical limb ischemia in type 2 diabetes and may have diagnostic utility[2]. miR-4739 is considered a potential therapeutic target and biomarker, but remains largely experimental, with limited information on interacting drugs and safety in humans[1][2].

Other names

MIR4739hsa-mir-4739mir-4739

Direct targeting of messenger RNAs such as HOXC10, TIMP1, COL3A1. Negative regulation of angiogenic factors (such as VEGFA expression). Modulation of PI3K/AKT signaling via HOXC10 suppression. Potential regulation of lysosomal, axon guidance, and ubiquitin-mediated proteolysis pathways by post-transcriptional mRNA targeting.