Target intelligence / Profile preview

MicroRNA 4741 (miR-4741 (also MIR4741))

Target
miR-4741 (also MIR4741)
Molecular classification
MicroRNA, Non-coding RNA, Regulatory RNA
01

Overview

MicroRNA 4741 (miR-4741) is a small, non-coding RNA molecule involved in the regulation of gene expression at the post-transcriptional level[5]. In human studies, circulating levels of miR-4741 have been identified as independent risk factors and potential protective biomarkers for drug resistance in breast cancer[1]. This microRNA is part of a multi-miRNA signature used for predictive modeling of neoadjuvant chemotherapy response. Its mechanistic role is to bind messenger RNA transcripts and modulate their stability or translation, contributing to the control of cellular proliferation and cancer progression. miR-4741 is not a classical drug target but may serve as a diagnostic marker for patient selection or prognosis in oncology[1][5].

Other names
hsa-miR-4741mir-4741hsa-mir-4741MIR4741
02

Mechanism of action

miR-4741 is not a classical pharmacological target; mechanisms involve regulation of mRNA translation and stability, affecting downstream cellular responses

03

Biological functions

Post-transcriptional regulation of gene expressionModulation of cell proliferationDrug resistance in cancer (notably breast cancer)
04

Disease associations

Cancer (especially breast cancer drug resistance and potentially colon and rectal cancer through miRNA signature)
05

Biomarkers

miR-4741 (as a serum biomarker for neoadjuvant chemotherapy resistance in breast cancer patients)

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