MicroRNA 4763 (miR-4763)

MicroRNA 4763 (miR-4763 or MIR4763) is a non-coding RNA molecule classified as a microRNA. Like other microRNAs, miR-4763 regulates gene expression by binding to complementary sequences on target messenger RNAs (mRNAs), leading to translational repression or mRNA degradation[3][7]. Specifically, miR-4763-3p has been shown to directly regulate the mRNA of RASD2, a gene implicated in dopamine signaling in the brain, and thereby modulates D1- and D2-dependent CREB signaling pathways[5]. Alterations in miR-4763-3p levels affect the expression of related proteins (e.g., DRD2, β-arrestin2) and are associated with potential roles as a novel biomarker for certain CNS diseases[5]. Research on miR-4763 remains limited compared to well-studied microRNAs, and no direct drug interactions or clinical therapies targeting this microRNA have yet been established. As with other microRNA-based targets, therapeutic modulation poses challenges due to the broad gene networks implicated and potential safety concerns[7].

Other names

MIR4763miR-4763hsa-mir-4763miR-4763-3p

Antisense inhibition (via antimiRs or antagomirs): complementary oligonucleotides bind and suppress miR-4763 activity. Mimic-based upregulation: synthetic mimics increase miR-4763 levels or effects. Both approaches would alter the expression of direct targets such as RASD2.