microRNA 4793 (miR-4793)

microRNA 4793 (miR-4793, MIR4793) is a small non-coding RNA molecule that post-transcriptionally regulates gene expression, primarily by binding to complementary sequences in target mRNAs and mediating their suppression or degradation. miR-4793-3p is known to target genes such as Grem1 and modulate pathways including TGF-beta signaling, immune responses, and lipid metabolism. It shows altered expression in hepatic cirrhosis with bacterial infection and in glioblastoma cell lines, where it may serve as a biomarker or influence disease biology[1][3]. There are no known approved drugs that specifically target miR-4793; research is ongoing into broad miRNA-based therapeutic approaches. As with other microRNAs, manipulation of miR-4793 expression must be approached with caution due to its pleiotropic effects and the complexity of gene regulatory networks[2][5]. If structured data is required for downstream applications (e.g., computational modeling, drug discovery), note that microRNAs like miR-4793 are most often considered regulators of targets, rather than standalone therapeutic targets.

Other names

MIR4793hsa-mir-4793microRNA-4793-3pmiR-4793-3p

miR-4793 negatively regulates mRNA targets such as Grem1 by binding their 3’-UTRs, leading to mRNA degradation or translational repression; in experimental systems, overexpression downregulated Grem1 and impacted TGF-beta signaling, altered lipid metabolism in cell models