MicroRNA 4796 (miR-4796)

MicroRNA 4796 (miR-4796) is a small, non-coding RNA molecule (microRNA) found in humans, acting as a post-transcriptional regulator of gene expression. It is most studied for its ability to modulate the DNA damage response in breast cancer cells, enhancing sensitivity to radiation by suppressing key DNA repair proteins (ATM, BRCA1, PARP, RAD51)[4]. Functionally, miR-4796 also plays a role in pathways related to cellular signaling and phosphorylation, and is involved in the pathogenesis and as a biomarker in lupus nephritis, where elevated levels in serum exosomes correlate with disease state and distinguish it from other autoimmune nephropathies[2]. There are no current drugs that target it directly, but its modulation is of interest for both cancer treatment strategies and non-invasive diagnosis/prognosis in autoimmune kidney disease.

Other names

hsa-miR-4796MIR4796mir-4796hsa-mir-4796-5p

In cancer research, miR-4796 sensitizes cells to radiotherapy by downregulating DNA damage repair genes, leading to increased radiation-induced cell death. As a biomarker, its serum levels reflect disease state/activity but do not mediate a drug mechanism.