MicroRNA 4804 (MIR4804)

MicroRNA 4804 (MIR4804) is a small, non-coding RNA molecule (20-24 nucleotides) transcribed from its gene as a long primary transcript, which is processed into a stem-loop precursor and then into the mature form by Drosha and Dicer RNase III enzymes. Once mature, MIR4804 is loaded into an RNA-induced silencing complex (RISC) where it base-pairs with target mRNAs—most notably the CMKLR1 gene—and inhibits their translation or promotes their degradation. MIR4804 plays a role in human monocyte immune function by regulating cytokine secretion and cell proliferation, and may contribute to immune homeostasis especially in chronic hepatitis B infection. Altered expression of MIR4804 has been associated with immunodeficiency and hair disorders, and predicted functional analysis links this microRNA to cancer and extracellular matrix-receptor interactions[1][2][3][6]. Direct drug interactions and clinical biomarker applications are yet to be established for MIR4804.

Other names

hsa-mir-4804hsa-miR-4804MIR4804

Inhibition of target gene CMKLR1 (chemokine-like receptor 1) expression. Translational inhibition of mRNAs via imperfect base pairing. Destabilization of mRNA.