microRNA 486-1 (miR-486-1)

microRNA 486-1 is a highly conserved, small non-coding RNA transcribed from the MIR486-1 locus, involved in post-transcriptional regulation of diverse target genes by RNA silencing mechanisms. It plays a tumor-suppressive role in several cancers (notably non-small cell lung cancer, breast cancer, and mesothelioma), affecting cell proliferation, apoptosis, epithelial-mesenchymal transition, chemoresistance, and the immune microenvironment. Circulating miR-486-1 has emerged as a sensitive biomarker for cancer diagnosis and prognosis; its pleiotropic regulatory effects are mediated through intricate protein–protein interaction networks and pathway modulations. Current research highlights both its utility as a biomarker and as a therapeutic target, especially via miRNA mimicry or inhibition approaches, although clinical application is challenged by biological variability and delivery technologies.

Other names

MIR486-1hsa-mir-486MIR486MIRN486hsa-mir-486-1mir-486-1microRNA 486miR-486-5pmiR-486-3p

Drugs or therapeutics targeting miR-486-1 typically act through either mimicking its function (miRNA mimics) or inhibiting its activity (anti-miRNA oligonucleotides). In cancer, increasing miR-486-1 levels can suppress oncogene expression, inhibit cell proliferation, arrest cell cycle, and enhance sensitivity to chemotherapy agents like cisplatin. Combination with other miRNAs (e.g., miR-21) increases overall efficacy of diagnostic panels and potentially therapeutic approaches.