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Target intelligence / Profile preview
MicroRNA 486-2 (MIR486-2)
- Target
- MIR486-2
- Molecular classification
- Other (microRNA, non-coding RNA)
01
Overview
MicroRNA 486-2 (MIR486-2) is a gene encoding a non-coding RNA of the microRNA family, producing mature forms such as miR-486-5p and miR-486-3p[3][5]. These microRNAs regulate gene expression by destabilizing or inhibiting translation of target mRNAs within the cell. miR-486-2 is implicated in multiple cancer types, particularly non-small cell lung cancer, where it is both a diagnostic/prognostic biomarker and a modulator of immune response and tumor biology[1][5]. Functional pathways influenced by this microRNA include cell cycle progression, apoptosis, epithelial-mesenchymal transition, chemoresistance, and immune cell infiltration[1]. Research highlights its pleiotropic effects on cancer risk, progression, and therapeutic resistance, but MIR486-2 is not a protein, receptor, enzyme, or transporter, and thus is not considered a classic therapeutic target[3][5].
- Other names
- hsa-mir-486-2mir-486-2microRNA mir-486-2MIR486-2
02
Mechanism of action
Not applicable (microRNAs act by regulating translation and stability of messenger RNAs, not by serving as binding targets for conventional drugs)
03
Biological functions
Post-transcriptional regulation of gene expressionCell proliferationCell cycle regulationApoptosisImmune response regulationEpithelial-mesenchymal transitionChemoresistance
04
Disease associations
Cancer (notably non-small cell lung cancer, breast cancer)Cardiovascular diseaseNeurodevelopmental diseaseMetabolic syndrome
05
Safety considerations
Not directly targetable by current drugstherapeutic modulation faces challenges with off-target effects, delivery, and specificity
06
Biomarkers
Circulating levels (in plasma/serum) used as diagnostic and prognostic biomarkers in non-small cell lung cancer, potentially in combination with other microRNAs
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