MicroRNA 489 (miR-489)

MicroRNA 489 (miR-489) is a highly conserved small non-coding RNA (miRNA) within the mammalian genome and is primarily involved in post-transcriptional gene regulation by binding to mRNA targets, resulting in their degradation or translational inhibition. It is transcribed from an intron within the CALCR (calcitonin receptor) gene. MiR-489 plays important biological roles, notably maintaining muscle stem cell (satellite cell) quiescence by suppressing the oncogene DEK, and acting as a tumor suppressor in several cancers—including breast, head and neck, and kidney—by targeting oncogenes such as HER2 (ERBB2), PTPN11 (SHP2), and HDAC2, thereby regulating cell proliferation, survival, and differentiation. Downregulation of miR-489 is associated with increased cell proliferation and tumor progression, while its restoration or overexpression can inhibit cancer cell growth and may serve as a potential therapeutic approach. It also plays a role in the inhibition of cardiac fibroblast proliferation and fibrosis. The expression pattern of miR-489 and its targets makes it a biomarker candidate for patient stratification and prognosis in oncology.

Other names

hsa-mir-489MIRN489MIR489mir-489

Post-transcriptional inhibition of target oncogenes such as DEK, HER2/ERBB2, PTPN11 (SHP2), HDAC2, etc. Down-regulation of oncogenic signaling pathways including HER2-SHP2-MAPK.