MicroRNA 492 (miR-492)

MicroRNA 492 (miR-492) is a small non-coding RNA molecule encoded by the human genome, involved in the regulation of gene expression by binding to complementary sequences in target messenger RNAs, leading to translational repression or degradation. Its dysregulation has been implicated in multiple cancer types, acting as either a tumor promoter (e.g., hepatocellular carcinoma, bladder cancer) or a tumor suppressor (e.g., osteosarcoma, clear cell renal cell carcinoma), depending on cellular context and gene targets. miR-492 directly targets genes such as PTEN, PAK7, and GJB4, modulating cell proliferation, migration, apoptosis, and invasion. Its expression patterns in tissues and serum make it a candidate diagnostic and prognostic biomarker for several malignancies, and it is increasingly viewed as a potential therapeutic target in cancer research[1][2][3][4][5].

Other names

MIR492hsa-mir-492MIRN492

Epigenetic modulation (demethylating agents can increase miR-492 expression); Post-transcriptional silencing of target mRNAs (e.g., PTEN in hepatocellular carcinoma, PAK7 in osteosarcoma, GJB4 in bladder cancer); Activation or suppression of cell signaling pathways (e.g., PI3K/AKT, via PTEN regulation)