MicroRNA 495 (miR-495)

MicroRNA 495 is a small non-coding RNA (miRNA) encoded on human chromosome 14q32.31, functioning as a regulatory molecule in post-transcriptional gene silencing. It is processed from a single-exon gene, producing two mature forms (miR-495-3p and miR-495-5p). miR-495 regulates diverse cellular processes including development, differentiation, proliferation, apoptosis, and drug resistance. Its role in cancer is context-dependent: it is commonly downregulated and acts as a tumor suppressor (notably in AML, gastric, and lung cancers), but upregulated in some cancers (like breast and hepatocellular carcinoma), acting as an oncogene. The molecule has growing relevance as a diagnostic, prognostic, and therapeutic target, with ongoing research to elucidate mechanisms of regulation, context-specific roles, and therapeutic applications.

Other names

MIR495hsa-mir-495mir-495MIRN495miRNA-495miR-495-3pmiR-495-5p

miR-495-based therapies can inhibit translation or promote degradation of target mRNAs (e.g., PBX3, MEIS1 in AML; JAM-A in breast cancer). Modulation of drug resistance through upregulation/downregulation of ATP-binding cassette transporters (e.g., MDR1)