MicroRNA-498 (miR-498)

MicroRNA-498 is a small, non-coding RNA molecule that regulates gene expression by binding to complementary sequences in target mRNAs, leading to their degradation or translational repression[7]. It has been characterized as a tumor suppressor in colorectal and lung cancer, where its expression is typically reduced, leading to increased cell proliferation, decreased apoptosis, and enhanced invasion[2][3][5]. Conversely, in triple-negative breast cancer, miR-498 can act as an oncogene by downregulating the tumor suppressor PTEN and BRCA1, thereby promoting cell proliferation and cancer progression[1][4]. Its specific targets include genes like BRCA1, PTEN, BCL-2, and WT1, and its expression level is associated with prognosis in various cancers. Interventions to modulate miR-498 expression (via mimics or inhibitors) are experimental approaches to cancer therapy, though challenges remain regarding delivery and specificity[1][2][3][4][5].

Other names

miR-498microRNA-498

Mimics: Restore miR-498 function to suppress oncogenes or restart tumor suppressive pathways. Inhibitors/decoys: Block miR-498 function to prevent downregulation of tumor suppressors or promote cell death.