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microRNA 5003 (MIR5003)
- Target
- MIR5003
- Molecular classification
- Non-coding RNA, microRNA, RNA gene regulator
01
Overview
microRNA 5003 (MIR5003) is a human, small non-coding RNA molecule that functions primarily in the post-transcriptional regulation of gene expression by binding to complementary sequences in target mRNAs, resulting in gene silencing via translational repression or mRNA degradation. The miR-5003-3p strand is overexpressed in liver cancer and has been shown to promote tumor progression by downregulating the expression of genes such as ABAT, BHMT, and SHMT1, which are associated with improved patient prognosis when highly expressed. MIR5003's dysregulation makes it a potential prognostic biomarker and therapeutic target in liver cancer[1][3][4].
- Other names
- hsa-mir-5003MIR5003miR-5003-3p
02
Mechanism of action
Guides miRNA-induced silencing complex (miRISC) to target mRNAs, leading to translational repression and/or degradation of specific targets (such as ABAT, BHMT, and SHMT1 in liver cancer context)
03
Biological functions
Post-transcriptional regulation of gene expressionInhibition of target gene translationmRNA degradation (via miRNA-induced silencing complex, miRISC)Regulation of cell proliferation, migration, and invasion in hepatic cells
04
Disease associations
Cancer (notably, liver cancer)Prognostic biomarker in liver cancer
05
Safety considerations
Potential for off-target gene regulation and pleiotropic effects common to miRNA-based therapeuticsImpact on metabolic and cancer-related pathways
06
Biomarkers
miR-5003-3p tissue expression (biomarker for liver cancer diagnosis and prognosis)Target mRNAs (ABAT, BHMT, SHMT1) protein expression
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