microRNA 504 (miR-504)

microRNA 504 (miR-504) is a small non-coding RNA (~22 nucleotides) involved in post-transcriptional regulation of gene expression by binding complementary sequences in target mRNAs, leading to their degradation or translational repression[6][7]. miR-504 resides within the FGF13 gene and directly targets the mRNA encoding the tumor suppressor p53, reducing p53 levels and attenuating cell-cycle arrest and apoptotic responses[7]. Dysregulation of miR-504 has been linked to various cancers, where it may act as a tumor suppressor (in hepatocellular carcinoma[2], retinoblastoma[3], NSCLC[4], gliomas[5]) or an oncomiR by quenching p53 activity, thus promoting tumorigenesis[7]. Beyond cancer, miR-504 modulates neurological disorders, diabetes, and stemness in glioma stem cells through its actions on pathways such as Wnt/β-catenin and others[1][5]. Changes in its expression can serve as a biomarker for disease and therapy response. Research into miR-504 also explores its potential as a therapeutic target using mimics or inhibitors in various preclinical models[1][2][3][4][5][7].

Other names

MIR504hsa-mir-504mir-504MIRN504miR-504-3p

Gene silencing via binding to target mRNA (e.g., TP53 for p53 suppression, FZD7 to suppress Wnt/β-catenin signaling, AEG-1/metadherin in retinoblastoma, IFITM1 in NSCLC, GRB10, EGR2); Modulation of pathways: p53 pathway, Wnt/β-catenin pathway, mesenchymal transition