MicroRNA 505 (miR-505)

MicroRNA 505 (miR-505) is a small, non-coding RNA belonging to the microRNA family, involved in the post-transcriptional regulation of gene expression by binding to target mRNAs and inhibiting their translation or promoting their degradation. It is frequently downregulated in multiple cancer types, where it functions as a tumor suppressor. miR-505 inhibits cancer cell proliferation, migration, invasion, and metabolic reprogramming by targeting several oncogenes such as IGF-1R, HK2, CDK5, and others. Restoring miR-505 expression in tumor models suppresses malignancy and sensitizes cells to chemotherapy. Low miR-505 levels are associated with advanced disease stage, metastasis, and worse overall survival, highlighting its relevance as a prognostic marker and potential therapeutic target.

Other names

hsa-miR-505MIR505MIRN505hsa-mir-505mir-505

Tumor suppression by direct targeting and inhibition of oncogenes (e.g., IGF-1R, HK2, HMGB1, CDK5, TGF-α, FZD4, WNT7B, MAP3K3, NRCAM, RUNX2); Interfering with signaling pathways involved in cell proliferation, metabolism, and survival