microRNA-506-3p (miR-506-3p)

microRNA-506-3p (miR-506-3p) is a small non-coding RNA molecule that functions as a critical post-transcriptional regulator of gene expression by binding to the 3'-untranslated regions (3'-UTRs) of target mRNAs (NIH, 2020; Frontiers in Oncology, 2024). Located on the X chromosome (Xq27.3) as part of the miR-506-514 cluster, it is predominantly characterized as a potent tumor suppressor in various human malignancies, including ovarian, lung, and breast cancers (HUGO Gene Nomenclature Committee; NIH, 2020). By targeting oncogenes such as SNAI2, YAP1, and RAD51, miR-506-3p inhibits essential oncogenic processes like the epithelial-mesenchymal transition (EMT), cell proliferation, and chemoresistance (ResearchGate, 2020; NIH, 2024). Its expression is frequently downregulated in malignant tissues, which often correlates with poor clinical outcomes and advanced disease stages, making it a valuable prognostic biomarker (NIH, 2020; Frontiers in Oncology, 2024). Therapeutic strategies involving miR-506-3p mimics are currently being explored to restore its suppressive function and enhance the efficacy of conventional treatments (MDPI, 2023; NIH, 2024). However, challenges such as off-target effects and its potential oncogenic role in specific contexts, like melanoma, necessitate careful evaluation for clinical application (Frontiers in Oncology, 2024; NIH, 2024).

Other names

hsa-miR-506-3pMIR506MIRN506microRNA 506

Post-transcriptional gene silencing via binding to the 3'-untranslated region (3'-UTR) of target mRNAs, leading to mRNA degradation or translational inhibition.