MicroRNA 510 (miR-510)

MicroRNA 510 (miR-510) is a small, non-coding RNA molecule belonging to the microRNA (miRNA) family that regulates gene expression by binding to complementary sequences on target messenger RNAs (mRNAs), resulting in their translational repression or degradation[1][5]. miR-510 is implicated in diverse biological functions, including cell proliferation, migration, invasion, apoptosis, and maintenance of redox homeostasis. It is notable for its dual role in cancer: acting as an oncogene in some settings (such as breast and thyroid cancer) by promoting tumor cell growth and migration, but functioning as a tumor suppressor in other contexts (such as renal cell carcinoma) through inhibition of proliferation and induction of apoptosis[2][4][7]. Its direct targets include PRDX1, a redox-regulating protein, and it is itself regulated by pathways such as PI3K/Akt[2]. Altered expression of miR-510 is associated with several malignancies and potentially other diseases such as hypertension. However, no approved drugs directly target miR-510; research is ongoing for therapeutic strategies based on antisense inhibition or miRNA mimics. Key supporting details: - miR-510 directly regulates genes such as PRDX1 (peroxiredoxin 1) and influences pathways including PI3K/Akt[2][4]. - Overexpression promotes oncogenic activities (proliferation, migration, tumor growth), while in other settings, such as renal cell carcinoma, it may suppress these phenotypes[2][4][7]. - Member of the miR-506/514 gene cluster[3]. - Its expression and function can be epigenetically regulated (e.g., by methylation)[5][6]. - No clinically approved drugs directly interact with miR-510 as of the current knowledge[1].

Other names

hsa-mir-510MIRN510mir-510MIR510miR-510-5p

Antisense oligonucleotide inhibition or mimics may modulate miR-510 activity, impacting cell proliferation, migration, and apoptosis[2][4]