MicroRNA 513a-1 (MIR513A1)

MicroRNA 513a-1 (MIR513A1) is a short non-coding RNA gene (microRNA) that regulates gene expression post-transcriptionally, primarily by affecting mRNA stability and translation through the RNA-induced silencing complex[2]. MIR513A1 is processed from a primary transcript via Drosha and Dicer, resulting in mature miRNA strands, and participates in the post-transcriptional inhibition or destabilization of specific target mRNAs. Experimental data has shown that the upregulation of miR-513a-5p, a mature form of this microRNA, is associated with increased breast cancer risk and acts as a negative regulator of the progesterone receptor in breast cancer cells[1]. MIR513A1, part of the miRNA family, is implicated as an oncogenic miRNA and a potential long-term biomarker for cancer risk assessment[1][2]. No drugs directly target this miRNA, and its main role is regulatory, not as a traditional therapeutic target or protein receptor.

Other names

hsa-mir-513-1hsa-mir-513a-1MIRN513-1MIRN513A1microRNA 513-1