MicroRNA 513a-2 (MIR513A2)

MicroRNA 513a-2 (MIR513A2) is a human microRNA gene encoding a short (20–24 nucleotide) non-coding RNA that functions primarily in *post-transcriptional regulation of gene expression* by targeting messenger RNA (mRNA) for degradation or translational repression. MIR513A2 is processed from a primary transcript to a mature microRNA that is incorporated into the RNA-induced silencing complex (RISC). One of its validated functions is the regulation of *luteinizing hormone/chorionic gonadotropin receptor gene expression in granulosa cells*, and it has been implicated in the regulation of cell metabolism and proliferation in cancers such as colorectal cancer, where it directly targets and represses hexokinase 2 (HK2) expression[1][2][4].\n\n**Interpretation of ambiguous fields:**\n- MIR513A2 is not considered a therapeutic target like a receptor or enzyme but is a regulatory non-coding RNA, sometimes explored as a potential *therapeutic approach* (for instance, in cancer), but not itself a direct pharmacological target in the same sense as proteins[1][2].\n- There are currently no documented clinically approved drugs interacting with or targeting MIR513A2, nor established mechanisms of action for drugs acting directly on this microRNA[2].\n- No established biomarkers or safety concerns specific to MIR513A2 targeting are reported in available literature.

Other names

hsa-mir-513a-2MIRN513-2MIRN513A-2MIRN513A2hsa-mir-513-2microRNA 513-2