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Target intelligence / Profile preview
MicroRNA 513b (miR-513b)
- Target
- miR-513b
- Molecular classification
- MicroRNA, Non-coding RNA, RNA
01
Overview
MicroRNA 513b is a non-coding RNA (microRNA) involved in post-transcriptional regulation of gene expression, typically by binding to specific mRNAs and inhibiting their translation or promoting their degradation[3]. It has been studied as a regulator of cell proliferation and apoptosis, notably acting as a tumor suppressor in cancers such as retinoblastoma by targeting TRIB1 and inhibiting the AKT/mTOR signaling pathway; however, it may also act as an oncogene in other cancers (e.g., cervical and ovarian cancer), suggesting context-dependent functions[2]. MIR513B and its mature form miR-513b-5p are encoded on the X chromosome and may serve as biomarkers or putative therapeutic targets for several cancers and certain developmental conditions[2][3]. No direct drug interactions are currently reported.
- Other names
- hsa-mir-513bMIRN513BMIR513Bhsa-miR-513b-5p
02
Biological functions
Post-transcriptional regulation of gene expressionModulation of cell proliferationPromotion or inhibition of apoptosisRegulation of AKT/mTOR signaling pathway
03
Disease associations
Cancer (retinoblastoma, non-small cell lung cancer, gastric cancer, ovarian cancer, embryonal testis carcinoma)Testicular development and male sexual maturationIntracranial aneurysm (through regulation of COL1A1 and COL1A2)
04
Safety considerations
Potential context-dependent oncogenic versus tumor-suppressive roles in different cancer types
05
Biomarkers
miR-513b-5p as potential diagnostic/prognostic biomarker in retinoblastoma and various cancersPossible biomarker for intracranial aneurysm via COL1A1/2 targeting
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