MicroRNA 514a-2 (MIR514A2)

MicroRNA 514a-2 (MIR514A2) is a short, non-coding RNA of 20–24 nucleotides, classified as a microRNA (miRNA)[1]. It functions in multicellular organisms to regulate post-transcriptional gene expression by binding to target messenger RNAs (mRNAs), mainly resulting in translational repression or mRNA destabilization[1]. miR-514a-2 is generated from a hairpin precursor by Drosha and Dicer nucleases and incorporated into the RNA-induced silencing complex (RISC)[1]. Like other miRNAs, its dysregulation is implicated in disease processes. miR-514a-2 has been identified as differentially expressed in various cancers, including hepatocellular carcinoma, where its altered expression is statistically associated with differences in patient survival, suggesting a role as a potential biomarker in oncology[3]. However, MIR514A2 itself is not generally considered a direct therapeutic target, such as a receptor, enzyme, or transporter, and no drugs are currently known to target it directly[1][3]. MIR514A2's principal function is as a regulatory non-coding RNA that modulates gene expression at a post-transcriptional level[1][5]. It is not a receptor, enzyme, or traditional therapeutic target, but its expression patterns may serve as disease biomarkers, particularly in oncology[3][5]. Studies show miR-514a-2 is among miRNAs differentially expressed in cancer, affecting cell processes such as adhesion, proliferation, and development, but detailed mechanisms and validated interacting drugs or inhibitors have not been established[3]. Aliases include several closely related names as listed above[1]. No contraindications, safety concerns, or drug interaction profiles are documented for MIR514A2, reflecting its current role as a biomolecular marker rather than a pharmacological target[1][3].

Other names

hsa-mir-514-2MIR514-2MIRN514-2hsa-mir-514a-2microRNA 514-2