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MicroRNA 514b (MIR514B)
- Target
- MIR514B
- Molecular classification
- microRNA, Non-coding RNA, Regulatory RNA molecule
01
Overview
MicroRNA 514b is a non-coding, regulatory RNA molecule expressed as two functional strands (miR-514b-3p and miR-514b-5p) which perform distinct roles in cancer biology. MiR-514b-3p typically acts as a tumor suppressor, inhibiting cell invasion, metastasis, and drug resistance, while miR-514b-5p promotes metastasis and chemoresistance through EMT modulation. These molecules primarily function by binding to and regulating the translation of specific mRNAs, affecting expression of genes such as CDH1, CLDN1, NTN1, and FZD4. Their expression balance serves as a biomarker for diagnosis and prognosis in cancers, with therapeutic prospects for modulating their activity to counteract tumor progression and drug resistance[1][2][4].
- Other names
- hsa-mir-514bmir-514bMIR514B
02
Mechanism of action
Regulation of target genes involved in EMT and drug resistance, such as CDH1 (E-cadherin), CLDN1 (claudin-1), FZD4, NTN1 Modulation of mRNA stability and translation by binding to specific sequences
03
Biological functions
Post-transcriptional regulation of gene expressionRegulation of cell migrationRegulation of invasion and metastasisModulation of epithelial-mesenchymal transition (EMT)Regulation of drug resistance
04
Disease associations
Cancer (especially colorectal cancer, ovarian cancer, testicular germ cell tumor, melanoma, renal cell carcinoma)Drug resistance (notably to chemotherapy agents such as cisplatin and irinotecan)
05
Safety considerations
Potential for off-target effects due to broad regulatory roles of miRNAsTherapeutic delivery challenges (specificity, delivery to target tissue)
06
Interacting drugs
Cisplatin (CDDP)
2 more in the full profile.
07
Biomarkers
Expression ratios of miR-514b-3p to miR-514b-5p for diagnosis, prognosis, and monitoring CRC progressionmiR-514b levels for predicting drug resistance, tumor stage, and lymph node invasion
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