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MicroRNA 516a-1 (MIR516A1)

Target: MIR516A1
Molecular classification: microRNA, non-coding RNA

Overview

MicroRNA 516a-1 is a small (20–24 nt) non-coding RNA transcribed as part of a primary microRNA transcript; after processing, the mature form regulates gene expression primarily via recognition and inhibition of target mRNAs. In cancer, especially bladder cancer, miR-516a-1 promotes metastasis and invasion by modulating the PHLPP2/AKT/FOXO3A/SMURF1/MMP9 pathway, making it a potential diagnostic and therapeutic target for metastatic disease[1][3].

Other names: hsa-mir-516-1hsa-mir-516a-1MIRN516-1MIRN516A-1MIRN516A1mir-516a-1microRNA 516-1

Mechanism of action

translational inhibition and destabilization of target mRNAs via the RNA-induced silencing complex (RISC); promotes metastasis by downregulating PHLPP2, activating the AKT/FOXO3A/SMURF1 axis, stabilizing MMP9, and increasing cell motility/invasion[1][3]

Biological functions

post-transcriptional regulation of gene expressioncell migrationcell invasionmetastasistranslational inhibition

Disease associations

cancer (especially bladder cancer metastasis)other (potential involvement in other pathologies via gene regulation, but evidence strongest for cancer)

Safety considerations

therapeutic targeting of microRNAs can present challenges such as off-target effects and delivery issues

Biomarkers

overexpression may serve as a biomarker for metastatic bladder cancer

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