MicroRNA 516b-1 (MIR516B1)

MicroRNA 516b-1 (MIR516B1) is a member of the microRNA family, a class of small, non-coding RNAs that regulate gene expression primarily at the post-transcriptional level. MIR516B1 is significantly downregulated in certain malignancies, including ameloblastoma, non-small cell lung cancer, primary melanoma, and prolactinomas, suggesting a tumor suppressive role. Experimental evidence shows that overexpression of MIR516B1 in ameloblastoma cells inhibits cell proliferation, migration, and invasion, and induces cell cycle arrest and apoptosis. Mechanistically, MIR516B1 directly targets MYCBP (Myc binding protein), affecting downstream proteins such as c-myc, RECK, MMP2, and MMP9, which are involved in oncogenic signaling and extracellular matrix remodeling. Although MIR516B1 has not yet been associated with any approved therapeutic drugs, its expression profile suggests utility as a biomarker for cancer progression and aggressiveness[1][2].

Other names

hsa-mir-516-4hsa-mir-516b-1MIRN516-4MIRN516B-1MIRN516B1mir-516b-1microRNA 516-4MIR516B1

Post-transcriptional regulation of gene expression; tumor suppression via downregulation of oncogenic pathways (MYCBP/c-myc/RECK/MMPs)