MicroRNA 516b-2 (MIR516B2)

MicroRNA 516b-2 is a non-coding RNA gene that produces a mature miRNA (miR-516b) involved in post-transcriptional regulation of target gene expression by binding to the 3' untranslated region (UTR) of mRNA, causing degradation or inhibition of translation[1][2][3]. In several cancers, including ameloblastoma, miR-516b-2 is significantly downregulated in tumor compared to normal tissues[1][2]. Experimental overexpression of miR-516b-2 suppresses tumor cell proliferation, migration, and invasion through direct targeting of genes such as MYCBP (Myc binding protein) and subsequent modulation of pathways involving c-myc, RECK, and MMPs (matrix metalloproteinases)[1][2]. The evidence supports a tumor suppressive role for miR-516b-2, making it a candidate target for RNA-based therapies or as a biomarker for multiple cancers[1][2][3].

Other names

hsa-mir-516-3hsa-mir-516b-2MIRN516-3MIRN516B-2MIRN516B2mir-516b-2microRNA 516-3

miRNA mimics: Restoration of loss-of-function tumor suppressive activity (i.e., increasing miR-516b-2 levels to inhibit tumor proliferation/invasion). miRNA inhibitors (antagomirs): Suppression of miR-516b-2 activity where its activity may be pathological (not yet documented).