microRNA 517b (MIR517B)

microRNA 517b is a member of the microRNA family of small (~22 nucleotides), non-coding RNA molecules that regulate gene expression through base pairing with target mRNAs, resulting in translational repression or mRNA destabilization. MIR517B belongs to the C19MC cluster on chromosome 19, which is implicated in the regulation of cell differentiation, proliferation, and responses to external and internal stimuli. Its abnormal expression has been linked to disease states, particularly hepatocellular carcinoma, where related microRNAs (notably miR-517a from the same cluster) drive tumorigenic processes such as cell proliferation and invasion[2][3]. Detection of circulating MIR517B has also been proposed as a biomarker for immune-related diseases and cancer[4]. MIR517B acts by modulating key pathways at the post-transcriptional level and, as with many miRNAs, may impact a broad array of physiologic and pathologic functions[1][2][3][4].

Other names

hsa-mir-517bMIRN517Bmir-517bMIR517B

Drugs targeting this molecule would generally act by inhibiting or mimicking its activity, affecting gene expression relevant to disease pathogenesis[1].