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MicroRNA 517c (miR-517c)
- Target
- miR-517c
- Molecular classification
- microRNA, non-coding RNA, member of the C19MC microRNA cluster
01
Overview
MicroRNA 517c is a small, non-coding RNA molecule (miRNA) that regulates gene expression by targeting messenger RNAs (mRNAs) for degradation or translational repression. It is encoded within the primate-specific C19MC cluster located at chromosome 19q13.42 and is highly expressed in certain stem cell types and tumors. Overexpression of miR-517c and related cluster members has been linked to enhanced cell proliferation, migration, and invasion, particularly in hepatocellular carcinoma and angiosarcoma, suggesting an oncogenic ("oncomiR") role. miR-517c and its cluster associates are being investigated as potential biomarkers and molecular targets for cancer diagnosis and treatment[1][2][3][5].
- Other names
- hsa-miR-517cMIRN517CMIR517Chsa-mir-517c
02
Biological functions
post-transcriptional gene regulationcell proliferationcell migrationcell differentiationepithelial–mesenchymal transition
03
Disease associations
cancerhepatocellular carcinomaangiosarcomamelanotic neuroectodermal tumorplacenta-associated disorders
04
Safety considerations
as a non-coding RNA, typical small molecule drug off-target effects do not applychallenges include delivery and specificity of RNA-targeted therapies
05
Biomarkers
potential diagnostic marker for angiosarcomapossible subclassifier for hepatocellular carcinoma
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