MicroRNA 518b (miR-518b)

MicroRNA 518b (miR-518b) is a non-coding RNA from the C19MC cluster that modulates cellular gene expression by binding to mRNA target sequences, resulting in silencing via degradation or translation inhibition. It has a critical role in controlling cell proliferation, apoptosis, and angiogenesis, most notably acting as a tumor suppressor in glioblastoma by directly inhibiting PDGFRB expression[1]. miR-518b also facilitates trophoblast cell proliferation by targeting Rap1b and activating the Ras-MAPK pathway, playing a pathogenic role in preeclampsia[3]. Its dysregulation is linked to several human diseases, positioning it as a candidate for both disease biomarkers and therapeutic intervention[1][2][3].

Other names

hsa-mir-518bMIRN518Bmir-518bMIR518B

Direct silencing of target mRNA, leading to mRNA degradation or translational inhibition (targets include PDGFRB and Rap1b)[1][3] Suppression of oncogenic signaling pathways[1] Modulation of Ras-MAPK pathway via Rap1b targeting[3]