microRNA 5195 (miR-5195)

MicroRNA 5195 is a short, endogenous, noncoding RNA (microRNA) that regulates gene expression post-transcriptionally by binding to complementary sequences in the 3'-untranslated regions (3'-UTRs) of target messenger RNAs, thereby repressing their expression[1][2][4]. Functionally, miR-5195-3p acts as a tumor suppressor in various human cancers, where its overexpression inhibits cell proliferation, migration, invasion, and epithelial-mesenchymal transition, as well as sensitizes cells to chemotherapeutic agents such as paclitaxel, particularly in triple-negative breast cancer[1][2][3]. In liver cancer, miR-5195-3p targets SOX9 and TPM4. In retinal cells exposed to high glucose, it targets GMFB, reducing apoptosis and inflammation associated with diabetic retinopathy[1][2]. It is being explored as both a therapeutic target and a biomarker for disease monitoring and treatment stratification.

Other names

hsa-miR-5195hsa-mir-5195MIR5195miR-5195-3p

Regulates mRNA targets by base-pairing with 3'-UTRs, leading to repression or degradation of target mRNAs. Modulates chemosensitivity by downregulating resistance-associated genes (e.g., EIF4A2 in TNBC, SOX9 and TPM4 in hepatoma, KLF5 in bladder cancer, MYO6 in lung cancer, GMFB in retinal cells[1][2][3]).