MicroRNA 5197 (miR-5197)

MicroRNA 5197 (miR-5197) is a member of the human microRNA family, classified as a non-coding RNA involved in post-transcriptional gene regulation. It functions primarily by binding to the 3’ untranslated region (3’ UTR) of target mRNAs—most notably CDK6—resulting in downregulation of protein expression. In colorectal cancer, miR-5197 has been identified as a key modulator of cell radiosensitivity. Overexpression of miR-5197 increases sensitivity to ionizing radiation by inducing G1/S cell cycle arrest and inhibiting cell division through suppression of CDK6. Its expression level may have prognostic or predictive value for identifying tumors more likely to respond to radiotherapy, and it is under investigation as a potential biomarker and therapeutic modulator in cancer treatment settings[2]. There are no known direct drug compounds that target miR-5197, though drugs targeting its downstream effectors (such as CDK6 inhibitors like palbociclib) may have efficacy modulated by miR-5197 levels. The broader clinical significance and additional disease associations of miR-5197 remain under active study.

Other names

hsa-mir-5197MIR5197microRNA-5197-5pmiR-5197-5p

miR-5197 directly targets and suppresses CDK6, leading to inhibition of cell cycle progression (G1/S arrest) and increased radiosensitivity in colorectal cancer cells[2] No direct approved drug targets for miR-5197 itself