MicroRNA 519c (miR-519c)

MicroRNA 519c (miR-519c) is a primate-specific, small non-coding RNA processed from the C19MC cluster located on chromosome 19q13.41-42. It serves as a post-transcriptional regulator by binding to specific regions of target mRNAs, repressing their translation or facilitating degradation. miR-519c is implicated in controlling cell proliferation, cell cycle, and apoptosis primarily by targeting mRNAs such as HuR (ELAVL1) and HIF-1α, thereby affecting cancer cell growth and response to microenvironmental stress. miR-519c is downregulated in several cancers, such as breast and pancreatic cancer, and has been explored as a tumor suppressor, a biomarker, and an element of experimental combination therapeutics to overcome drug resistance[1][2][3][5].

Other names

hsa-mir-519cMIR519CMIRN519Cmir-519chsa-mir-519c-3p

miR-519c downregulates target mRNAs by binding their coding or untranslated regions, repressing translation or leading to degradation; known targets include HIF-1α mRNA and HuR (ELAVL1) mRNA, leading to reduction in protein levels and modulation of downstream pathways[1][3][5]