MicroRNA 523 (MIR523)

MicroRNA 523 (MIR523) is a short (20–24 nucleotide) non-coding RNA classified as a microRNA gene, part of the C19MC cluster located on chromosome 19[1][4]. MicroRNAs act as post-transcriptional regulators of gene expression by binding to complementary sequences in target mRNAs, resulting in translational inhibition or destabilization of these mRNAs[1]. MIR523’s products are transcribed by RNA polymerase II, processed from primary transcripts (pri-miRNAs) through the action of Drosha and Dicer ribonucleases, and incorporated into the RNA-induced silencing complex (RISC) where they exert their regulatory roles[1]. MIR523 is implicated in stem cell biology and tumorigenesis as part of the C19MC cluster, one of the largest human microRNA clusters that is expressed in embryonic stem cells and certain cancers[4]. While MIR523 has important regulatory functions in gene expression and disease processes, there are currently no approved drugs that specifically target MIR523, nor is it commonly used as a biomarker or considered a therapeutic target in the canonical sense[1][4].

Other names

hsa-mir-523MIRN523mir-523